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SV40 T Antigen Cell Immortalization Kit
Simplest and most reliable agent for the immortalization of many different cell types
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It is well known that primary cells only undergo a pre-determined and finite number of cell divisions in culture. After limited population doublings (the number of which varies by species, cell type, and culture conditions), primary cells enter a state, so-called replicative senescence, where they can no longer divide. To surpass senescence, several methods exist for immortalizing mammalian cells in culture. Simian virus 40 (SV40) T antigen has been shown to be the simplest and most reliable agent for the immortalization of many different cell types. Recent studies have also shown that SV40 T antigen can induce Telomerase activity in the infected cells.
| Product Name | SV40 T Antigen Cell Immortalization Kit |
|---|---|
| Shipping Condition |
Dry Ice - Overnight Shipping |
| Storage and Stability |
Store at -80 °C (stable up to 6 months) |
| Quality Control | The packaged lentivector constructs are provided as frozen VSV-G pseudotyped viral particles. The titer of the lentivirus is measured by Clontech's Lenti-X qRT-PCR Titration Kit (Cat. # 631235). Each lot of Cell Immortalization Kit is functionally tested in fibroblasts. |
| Restricted Use |
For Research Use Only. Not for use in diagnostic or therapeutic procedures. |
- Shoeibi S. et al., AAT-MSC-EVs: Novel implications for suppressing ferroptosis, fibrosis and pain associated with chronic pancreatitis. Mol Ther (2025)
- Chaudhary S. et al., Developmental pluripotency-associated 4 increases aggressiveness of pituitary neuroendocrine tumors by enhancing cell stemness. Neuro Oncol (2025)
- Ashraf S. et al., Modulation of ATM enhances DNA repair in G2/M phase of the cell cycle and averts senescence in Fuchs endothelial corneal dystrophy. Commun Biol (2024)
- Vidal M.S. Jr. et al., Establishment and comparison of human term placenta–derived trophoblast cells. Biol Reprod (2023)
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