Knockout Cell Lines
Alstem offers a series of knockout (KO) iPSC lines designed to support research in human disease modeling and therapeutic discovery. The parental iPSC line was generated from healthy human foreskin fibroblasts and reprogrammed through the transient ectopic expression of Yamanaka factors. Using precise CRISPR/Cas-mediated gene editing, we have developed a collection of disease-relevant KO iPSC lines that serve as powerful models for studying human development, neurodegeneration, cardiovascular disease, and rare genetic syndromes.
Highlights
- Derived from a well-characterized iPSC line.
- Gene knockouts introduced with precise CRISPR/Cas9 technology.
- Isogenic background ensures consistency across KO lines.
- Validated for pluripotency, genomic stability, and differentiation potential.
- Models cover a broad range of disease areas, from neurological disorders to cardiovascular syndromes.
Key Features
- High-quality iPSCs
- Reproducibility
- Scalability
Application
- Disease modeling
- Drug discovery and screening
- Functional genomics
- Cell differentiation studies