Human induced pluripotent stem cells (iPSCs) can be derived from somatic cells through a reprogramming process driven by ectopic expression of a defined set of reprogramming factors: Oct4, Sox2, Klf4 and c-Myc. These hiPSCs share the properties of self-renewal and pluripotency with human ES cells, and can therefore be used as a renewable source for all differentiated cell types of the body. Human iPSCs can be generated from patients of virtually any genetic background. Retroviruses are efficient tools for delivering heritable genes into the genome of dividing cells. The VSV-G pseudotyped retrovirus has a wide range of targets including both mammalian and non-mammalian cells, and are usually silenced in ES cells. The retrovirus is commonly used in generating iPSCs because of its high reprogramming efficiency. The Human iPS Cell Reprogramming Retrovirus Kit offers such opportunity to generate iPSCs from various tissues and cell types.